Unusual expression of LINE-1 transposable element in the MRL autoimmune lymphoproliferative syndrome-prone strain
نویسندگان
چکیده
منابع مشابه
LINE-1: a mammalian transposable element.
Correspondence: T.G. Fanning, Laboratory of Biochemistry, National Cancer Institute, Bldg. 37, Rm. 4A01, Bethesda, MD 20892, U.S.A. domesticus and Homo sapiens, respectively. This taxonomic differentiation of Lls is not superfluous, since structural differences exist between Lls from different taxonomic orders, and significant differences may even exist between Lls found in different genera wit...
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Among the 10(5) LINE-1 sequences (L1Hs) in the human genome are one or more 6-kb segments that are active retrotransposons. Expression of these retrotransposons appears to be favored in cells of germ line origin, as well as in some other tumor cells of epithelial origin. In such cells, the product of the first L1Hs open reading frame (ORF), a protein called p40, is detectable; p40 has no appare...
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1»Titu Maiorescu« University, Faculty of Medicine, Department of Physiology, Center for Rheumatic Diseases, Bucharest, Romania 2»Carol Davila« University of Medicine and Pharmacy, Clinic of Neurology, Colentina Clinical Hospital, Bucharest, Romania 3University of Medicine and Pharmacy, Department of Immunology, Craiova, Romania 4»Carol Davila« University of Medicine and Pharmacy, Clinical Hospi...
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Autoimmune lymphoproliferative Syndrome (ALPS) is a rare inherited disorder of apoptosis. It usually presents with chronic lymphadenopathy, splenomegaly, and symptomatic cytopenia in a child. Herein, we report a 14-year-old boy with symptoms misdiagnosed as hemophagocytic lymphohistiocytosis who was treated before ALPS was diagnosed for the patient. This case should alert pediatricians to consi...
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ژورنال
عنوان ژورنال: Oncogene
سال: 2002
ISSN: 0950-9232,1476-5594
DOI: 10.1038/sj.onc.1205730